Pleiotropic effects of statins in atherosclerosis: role on endothelial function, inflammation and immunomodulation.

@article{Arnaud2005PleiotropicEO,
  title={Pleiotropic effects of statins in atherosclerosis: role on endothelial function, inflammation and immunomodulation.},
  author={Claire Arnaud and François Mach},
  journal={Archives des maladies du coeur et des vaisseaux},
  year={2005},
  volume={98 6},
  pages={661-6}
}
Atherosclerosis and its complications still represent the major cause of death in developed countries. Statins have been described as the most potent class of drugs to reduce serum cholesterol levels. The effectiveness and rapidity of statin-induced decreases in coronary events led to the speculation that statins possess also cholesterol-independent effects. By the inhibition of 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase, an enzyme crucial to cholesterol synthesis, statins… CONTINUE READING

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