Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis.

@article{Frau2013PleiotropicEO,
  title={Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis.},
  author={Maddalena Frau and Francesco Feo and Rosa Maria Pascale},
  journal={Journal of hepatology},
  year={2013},
  volume={59 4},
  pages={830-41}
}
Downregulation of liver-specific MAT1A gene, encoding S-adenosylmethionine (SAM) synthesizing isozymes MATI/III, and upregulation of widely expressed MAT2A, encoding MATII isozyme, known as MAT1A:MAT2A switch, occurs in hepatocellular carcinoma (HCC). Being inhibited by its reaction product, MATII isoform upregulation cannot compensate for MATI/III decrease. Therefore, MAT1A:MAT2A switch contributes to decrease in SAM level in rodent and human hepatocarcinogenesis. SAM administration to… CONTINUE READING

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MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma.

The Journal of clinical investigation • 2013
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