Pleiotropic effects of cryptochromes 1 and 2 on free-running and light-entrained murine circadian rhythms.

@article{Gelder2002PleiotropicEO,
  title={Pleiotropic effects of cryptochromes 1 and 2 on free-running and light-entrained murine circadian rhythms.},
  author={Russell N Van Gelder and Therese M Gibler and Daniel C. Tu and Kris Embry and Christopher P. Selby and Carol L. Thompson and Aziz Sancar},
  journal={Journal of neurogenetics},
  year={2002},
  volume={16 3},
  pages={181-203}
}
Cryptochromes function in both light entrainment of circadian rhythms and in a peripheral circadian clock mechanism in Drosophila. Mice have two closely related cryptochrome genes (mCry1 and mCry2). To further understand the roles of mammalian cryptochromes, we bred mice to carry all possible combinations of wild-type and cryptochrome knockout alleles, and tested these mice for free-running and entrained circadian rhythmicity. We find that a single wild-type copy of mCry1, but not mCry2, is… CONTINUE READING

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