Pleiotropic effects of beneficial mutations in Escherichia coli.

@article{Ostrowski2005PleiotropicEO,
  title={Pleiotropic effects of beneficial mutations in Escherichia coli.},
  author={E A Ostrowski and Daniel E Rozen and Richard E. Lenski},
  journal={Evolution; international journal of organic evolution},
  year={2005},
  volume={59 11},
  pages={2343-52}
}
Micromutational models of adaptation have placed considerable weight on antagonistic pleiotropy as a mechanism that prevents mutations of large effect from achieving fixation. However, there are few empirical studies of the distribution of pleiotropic effects, and no studies that have examined this distribution for a large number of adaptive mutations. Here we examine the form and extent of pleiotropy associated with beneficial mutations in Escherichia coli. To do so, we used a collection of… CONTINUE READING