Pleiotropic effects of Pasteurella multocida toxin are mediated by Gq-dependent and -independent mechanisms. involvement of Gq but not G11.

@article{Zywietz2001PleiotropicEO,
  title={Pleiotropic effects of Pasteurella multocida toxin are mediated by Gq-dependent and -independent mechanisms. involvement of Gq but not G11.},
  author={Alexandra Zywietz and Antje Gohla and Monika Schmelz and Guenter Schultz and Stefan Offermanns},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 6},
  pages={3840-5}
}
Pasteurella multocida toxin (PMT) is a highly potent mitogen for a variety of cell types. PMT has been shown to induce various cellular signaling processes, and it has been suggested to function through the heterotrimeric G-proteins G(q)/G(11). To analyze the role of G(q)/G(11) in the action of PMT, we have studied the effect of the toxin in Galpha(q)/Galpha(11) double-deficient fibroblasts as well as in fibroblasts lacking only Galpha(q) or Galpha(11). Interestingly, formation of inositol… CONTINUE READING

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