Pleiotropic effects of HNF1A rs1183910 in a population-based study of 60,283 individuals

@article{Allin2013PleiotropicEO,
  title={Pleiotropic effects of HNF1A rs1183910 in a population-based study of 60,283 individuals},
  author={Kristine H Allin and B\orge G. Nordestgaard},
  journal={Diabetologia},
  year={2013},
  volume={57},
  pages={729-737}
}
According to genome-wide association studies (GWAS) a locus in the HNF1A gene has pleiotropic effects on several metabolic traits. In a large single-centre study we used the intronic variant rs1183910 located in a region with no or low recombination rate as an instrument for the HNF1A locus to evaluate pleiotropic effects of this locus on the risk of developing type 2 diabetes, as well as on body composition and levels of non-fasting glucose, lipids, acute-phase reactants, and biomarkers of… CONTINUE READING
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Talianidis I (1997)Modulation of hepatic gene expression by hepatocyte nuclear factor 1. Science 277:109–112

  • E Ktistaki
  • Diabetologia
  • 2014
1 Excerpt

Loci affecting γ-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease

  • RP Middelberg, B Benyamin, MH deMoor
  • 2012

Loci affecting γglutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations

  • RP Middelberg, B Benyamin, MH deMoor
  • HumMol Genet
  • 2012

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