Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity.

  title={Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity.},
  author={Benjamin J. Moeller and Matthew R. Dreher and Zahid N. Rabbani and Thies Schroeder and Yiting Cao and Chuan Yuan Li and Mark W. Dewhirst},
  journal={Cancer cell},
  volume={8 2},
We have previously shown that radiation increases HIF-1 activity in tumors, causing significant radioprotection of the tumor vasculature. The impact that HIF-1 activation has on overall tumor radiosensitivity, however, is unknown. We reveal here that HIF-1 plays an important role in determining tumor radioresponsiveness through regulating four distinct processes. By promoting ATP metabolism, proliferation, and p53 activation, HIF-1 has a radiosensitizing effect on tumors. Through stimulating… CONTINUE READING


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