Pleiotropic effect of the proton pump inhibitor esomeprazole leading to suppression of lung inflammation and fibrosis

@inproceedings{Ghebremariam2015PleiotropicEO,
  title={Pleiotropic effect of the proton pump inhibitor esomeprazole leading to suppression of lung inflammation and fibrosis},
  author={Yohannes T. Ghebremariam and John P Cooke and William Gerhart and Carol Griego and Jeremy B Brower and Melanie L. Doyle-Eisele and Benjamin C. Moeller and Qingtao Zhou and Lawrence A T Ho and Joao A de Andrade and Ganesh Raghu and Leif E. Peterson and Andreana L. Rivera and Glenn Rosen},
  booktitle={Journal of Translational Medicine},
  year={2015}
}
The beneficial outcome associated with the use of proton pump inhibitors (PPIs) in idiopathic pulmonary fibrosis (IPF) has been reported in retrospective studies. To date, no prospective study has been conducted to confirm these outcomes. In addition, the potential mechanism by which PPIs improve measures of lung function and/or transplant-free survival in IPF has not been elucidated. Here, we used biochemical, cell biological and preclinical studies to evaluate regulation of markers associated… CONTINUE READING
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