Pleiotropic effect of protein P6 on the viral cycle of bacteriophage phi29.

@article{Camacho2000PleiotropicEO,
  title={Pleiotropic effect of protein P6 on the viral cycle of bacteriophage phi29.},
  author={A. G. Camacho and M. Salas},
  journal={Journal of bacteriology},
  year={2000},
  volume={182 24},
  pages={6927-32}
}
The product of bacteriophage phi29 early gene 6, protein p6, is a double-stranded-DNA binding protein and one of the more abundant proteins during viral infection. We have studied the role of protein p6 in vivo through the infection of suppressor and nonsuppressor Bacillus subtilis strains with a phage carrying a nonsense mutation in gene 6, sus6(626). In the absence of functional protein p6, the two major processes of the viral cycle, transcription and DNA replication, were affected. Viral DNA… CONTINUE READING

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