Pleiotropic activity of lysophosphatidic acid in bone metastasis.

  title={Pleiotropic activity of lysophosphatidic acid in bone metastasis.},
  author={Olivier Peyruchaud and Raphael Leblanc and Marion A. David},
  journal={Biochimica et biophysica acta},
  volume={1831 1},
Bone is a common metastatic site for solid cancers. Bone homeostasis is tightly regulated by intimate cross-talks between osteoblast (bone forming cells) and osteoclasts (bone resorbing cells). Once in the bone microenvironment, metastatic cells do not alter bone directly but instead perturb the physiological balance of the bone remodeling process controlled by bone cells. Tumor cells produce growth factors and cytokines stimulating either osteoclast activity leading to osteolytic lesions or… CONTINUE READING
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Absence of the lysophosphatidic acid receptor LPA 1 results in abnormal

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