Pleiotropic Functions of Pituitary Adenylyl Cyclase-Activating Polypeptide on Retinal Ontogenesis: Involvement of KLF4 in the Control of Progenitor Cell Proliferation

@article{Njaine2014PleiotropicFO,
  title={Pleiotropic Functions of Pituitary Adenylyl Cyclase-Activating Polypeptide on Retinal Ontogenesis: Involvement of KLF4 in the Control of Progenitor Cell Proliferation},
  author={Brian Njaine and Mauricio Rocha-Martins and Carlos H. Vieira-Vieira and Luiz Dione Barbosa De-Melo and R. F. J. van Linden and Karen M. Braas and Victor May and Rodrigo A. P. Martins and Mariana Souza Silveira},
  journal={Journal of Molecular Neuroscience},
  year={2014},
  volume={54},
  pages={430-442}
}
We showed previously that the neuropeptide pituitary adenylyl cyclase-activating polypeptide (PACAP) negatively regulates proliferation of postnatal rat retinal progenitor cells through the downregulation of cyclin D1 in a cAMP/protein kinase A dependent manner. In the present study, we describe by microarray analysis several putative PACAP targets… CONTINUE READING