Pleiotropic Effects of IL-33 on CD4+ T Cell Differentiation and Effector Functions

@inproceedings{lvarez2019PleiotropicEO,
  title={Pleiotropic Effects of IL-33 on CD4+ T Cell Differentiation and Effector Functions},
  author={Fernando J. {\'A}lvarez and J{\"o}rg Hermann Fritz and Ciriaco A Piccirillo},
  booktitle={Front. Immunol.},
  year={2019}
}
IL-33, a member of the IL-1 family of cytokines, was originally described in 2005 as a promoter of type 2 immune responses. However, recent evidence reveals a more complex picture. This cytokine is released locally as an alarmin upon cellular damage where innate cell types respond to IL-33 by modulating their differentiation and influencing the polarizing signals they provide to T cells at the time of antigen presentation. Moreover, the prominent expression of the IL-33 receptor, ST2, on GATA3… CONTINUE READING

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Memory CD8+ T Cell Protection From Viral Reinfection Depends on Interleukin-33 Alarmin Signals

Claudia Baumann, Anja Froehlich, +3 authors Max Löhning
  • Front. Immunol.
  • 2019
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