Pleiotropic Effects of GIP on Islet Function Involve Osteopontin

@inproceedings{Lyssenko2011PleiotropicEO,
  title={Pleiotropic Effects of GIP on Islet Function Involve Osteopontin},
  author={Valeriya Lyssenko and Lena Eliasson and Olga B. Kotova and Kasper Pilgaard and Nils Wierup and Albert Salehi and Anna Wendt and Anna Jonsson and Yang Z. De Marinis and Lisa M Berglund and Jalal Taneera and Alexander Balhuizen and Ola Hansson and Peter Osmark and Pontus Dun{\'e}r and Charlotte Br{\o}ns and Alena Stan{\vc}{\'a}kov{\'a} and Johanna Kuusisto and Marco Bugliani and rachna. saxena and Emma Ahlqvist and Timothy J Kieffer and Tiinamaija Tuomi and Bo Isomaa and Olle Melander and Emily Sonestedt and Marju Orho-Melander and Peter Nilsson and Sara Bonetti and Riccardo C Bonadonna and Roberto Miccoli and Stefano Delprato and Piero Marchetti and Sten Madsbad and P. B. red. Poulsen and Allan Vaag and Markku Laakso and Maria F. Gomez and Leif Groop},
  booktitle={Diabetes},
  year={2011}
}
OBJECTIVE The incretin hormone GIP (glucose-dependent insulinotropic polypeptide) promotes pancreatic β-cell function by potentiating insulin secretion and β-cell proliferation. Recently, a combined analysis of several genome-wide association studies (Meta-analysis of Glucose and Insulin-Related Traits Consortium [MAGIC]) showed association to postprandial insulin at the GIP receptor (GIPR) locus. Here we explored mechanisms that could explain the protective effects of GIP on islet function… CONTINUE READING

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