Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche.

@article{Himburg2012PleiotrophinRT,
  title={Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche.},
  author={Heather A. Himburg and Jeffrey R. Harris and Takahiro Ito and Pamela Daher and J. Lauren Russell and Mamle Quarmyne and Phuong L Doan and Katherine L. Helms and Mai Nakamura and Emma Fixsen and Gonzalo Herrad{\'o}n and Tannishtha Reya and Nelson J Chao and Sheila Harroch and John P. Chute},
  journal={Cell reports},
  year={2012},
  volume={2 4},
  pages={964-75}
}
The mechanisms through which the bone marrow (BM) microenvironment regulates hematopoietic stem cell (HSC) fate remain incompletely understood. We examined the role of the heparin-binding growth factor pleiotrophin (PTN) in regulating HSC function in the niche. PTN(-/-) mice displayed significantly decreased BM HSC content and impaired hematopoietic regeneration following myelosuppression. Conversely, mice lacking protein tyrosine phosphatase receptor zeta, which is inactivated by PTN… CONTINUE READING
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