Pleiotrophin inhibits hippocampal long-term potentiation: a role of pleiotrophin in learning and memory.

@article{Olmo2009PleiotrophinIH,
  title={Pleiotrophin inhibits hippocampal long-term potentiation: a role of pleiotrophin in learning and memory.},
  author={Nuria del Olmo and Esther Gramage and Luis Fernando Alguacil and Pablo P{\'e}rez-Pi{\~n}era and Thomas F. Deuel and Gonzalo Herrad{\'o}n},
  journal={Growth factors},
  year={2009},
  volume={27 3},
  pages={189-94}
}
Pleiotrophin (PTN) is a growth factor that has been shown to be involved in hippocampal synaptic plasticity and learning. To further understand the involvement of PTN in memory processes, we performed in vitro electrophysiological studies in PTN-stimulated CA1 from rat hippocampal slices combined with the behavioural testing of PTN deficient (PTN - / - ) mice. We found that PTN inhibited hippocampal long-term potentiation (LTP) induced by high-frequency stimulation (HFS) consisted in three… CONTINUE READING

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