Pleiotrophin inhibits HIV infection by binding the cell surface‐expressed nucleolin

@article{Said2005PleiotrophinIH,
  title={Pleiotrophin inhibits HIV infection by binding the cell surface‐expressed nucleolin},
  author={Elias A. Said and Jos{\'e} Courty and Josette Svab and Jean Delbe and Bernard Krust and Ara G. Hovanessian},
  journal={The FEBS Journal},
  year={2005},
  volume={272}
}
The growth factor pleiotrophin (PTN) has been reported to bind heparan sulfate and nucleolin, two components of the cell surface implicated in the attachment of HIV‐1 particles to cells. Here we show that PTN inhibits HIV‐1 infection by its capacity to inhibit HIV‐1 particle attachment to the surface of permissive cells. The β‐sheet domains of PTN appear to be implicated in this inhibitory effect on the HIV infection, in particular the domain containing amino acids 60–110. PTN binding to the… 
Midkine, a cytokine that inhibits HIV infection by binding to the cell surface expressed nucleolin
TLDR
The potent and the distinct anti-HIV action of MK along with its enhanced expression in lymphocytes by various physiological stimuli, point out that MK is a cytokine that could be involved in HIV pathogenesis.
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TLDR
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TLDR
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TLDR
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Surface Expressed Nucleolin Is Constantly Induced in Tumor Cells to Mediate Calcium-Dependent Ligand Internalization
TLDR
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TLDR
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The lectin-binding pattern of nucleolin and its interaction with endogenous galectin-3
TLDR
It is shown for the first time that nucleolin and endogenous galectin-3 exist in the same complexes in the nucleolus, the cytoplasm, and on the cell surface of melanoma cells.
Identification of nucleolin as a cellular receptor for human respiratory syncytial virus
TLDR
It is shown that RSV interacts with host-cell nucleolin via the viral fusion envelope glycoprotein and binds specifically to nucleolin at the apical cell surface in vitro and RNAi-mediated knockdown of lung nucleolin was associated with a significant reduction in RSV infection in mice, confirming that nucleolin is a functional RSV receptor in vivo.
Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell type
TLDR
The results suggest that targeting surface nucleolin could change the organization of the 500-kDa complex to interfere with the proper functioning of surfaceucleolin and the associated proteins, and thus lead to distinct inhibitory mechanisms.
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