Pleiotrophin antagonizes Brd2 during neuronal differentiation.

  title={Pleiotrophin antagonizes Brd2 during neuronal differentiation.},
  author={Pablo Garc{\'i}a-Guti{\'e}rrez and Francisco Juarez-Vicente and Debra J. Wolgemuth and Mario Garc{\'i}a-Dom{\'i}nguez},
  journal={Journal of cell science},
  volume={127 Pt 11},
Bromodomain-containing protein 2 (Brd2) is a BET family chromatin adaptor required for expression of cell-cycle-associated genes and therefore involved in cell cycle progression. Brd2 is expressed in proliferating neuronal progenitors, displays cell-cycle-stimulating activity and, when overexpressed, impairs neuronal differentiation. Paradoxically, Brd2 is also detected in differentiating neurons. To shed light on the role of Brd2 in the transition from cell proliferation to differentiation, we… CONTINUE READING