Pleiotrophin, an embryonic differentiation and growth factor, is expressed in osteoarthritis.

@article{Pufe2003PleiotrophinAE,
  title={Pleiotrophin, an embryonic differentiation and growth factor, is expressed in osteoarthritis.},
  author={Thomas Pufe and Michaela Bartscher and Wolf J Petersen and Bernhard N. Tillmann and Rolf Mentlein},
  journal={Osteoarthritis and cartilage},
  year={2003},
  volume={11 4},
  pages={260-4}
}
OBJECTIVE Pleiotrophin (PTN) is a 15.3 kDa heparin-binding peptide, which is expressed in mesodermal and neuroectodermal cells during development, but rarely in adult tissues. In fetal or juvenile cartilage, PTN is an abundant protein and appears to be involved in chondrocyte differentiation. Since developmentally regulated factors often re-appear in the disease state, we examined PTN expression in cartilage and synovial fluid of patients with osteoarthritis (OA). METHODS PTN mRNA and protein… CONTINUE READING

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