Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus

@article{Mygind2005PlectasinIA,
  title={Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus},
  author={Per Holse Mygind and Rikke L. Fischer and Kirk Matthew Schnorr and Mogens Trier Hansen and Carsten P. S{\"o}nksen and Svend Ludvigsen and Dorotea Ravent{\'o}s and Steen Buskov and Bjarke Bak Christensen and Leonardo De Maria and Olivier Taboureau and Debbie S. Yaver and Signe Gry Elvig-J{\o}rgensen and Marianne Vind S{\o}rensen and Bj{\o}rn E Christensen and S{\o}ren Kj{\ae}rulff and Niels Frimodt-M{\o}ller and Robert I. Lehrer and Michael Zasloff and H. H. Kristensen},
  journal={Nature},
  year={2005},
  volume={437},
  pages={975-980}
}
Animals and higher plants express endogenous peptide antibiotics called defensins. These small cysteine-rich peptides are active against bacteria, fungi and viruses. Here we describe plectasin—the first defensin to be isolated from a fungus, the saprophytic ascomycete Pseudoplectania nigrella. Plectasin has primary, secondary and tertiary structures that closely resemble those of defensins found in spiders, scorpions, dragonflies and mussels. Recombinant plectasin was produced at a very high… Expand
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  • Journal of microbiology and biotechnology
  • 2016
TLDR
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