Pleconaril: a novel antipicornaviral drug.

  title={Pleconaril: a novel antipicornaviral drug.},
  author={Jos{\'e} Rafael Romero},
  journal={Expert opinion on investigational drugs},
  volume={10 2},
Pleconaril (VP-63843) 3-[3,5-dimethyl-4[[3-(3-methyl-5-isoxazolyl)propyl] oly]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole is a novel, broad spectrum antipicornaviral agent. Pleconaril binds to a hydrophobic pocket in the viral capsid inducing conformational changes, which lead to altered receptor binding and viral uncoating. Pleconaril is orally… CONTINUE READING