The product of the cph oncogene is a truncated, nucleotide-binding protein that enhances cellular survival to stress
Syrian hamster full-length cDNAs for the cph oncogene and proto-oncogene are isolated and show increased survival to various forms of stress, strongly suggesting that cph participates in cellular mechanisms of response to stress.
Gene‐trapping to identify and analyze genes expressed in the mouse hippocampus
Mice harboring random gene‐trap insertions of a lacZ (β‐galactosidase)‐neomycin resistance fusion cassette were analyzed for expression in the hippocampus, showing an increase in hippocampal CA1 long‐term potentiation (LTP), suggesting a role for this receptor in synaptic plasticity.
Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins
A single-molecule pulldown assay is employed to study interactions of lipid vesicles with full-length proteins in mammalian whole cell lysates and reveals unexpected lipid-binding specificity of PH domain-containing proteins.
12 Phospo-PKCs in Abeta 1-42-Specific Human T Cells from Alzheimer ’ s Disease Patients
It has been demonstrated that a subset of Amyloid-Beta1-42-specific Tcells, characterised by bright expression of Phosphorylated-Protein-Kinase C, distinguishes Alzheimer’s Disease from other neurodegenerative conditions.
Phosphotyrosine recognition domains: the typical, the atypical and the versatile
- BiologyCell Communication and Signaling
The more the authors learn about the biology and ultrastructural details of pTyr recognition domains, the more does it become apparent that nature cleverly combines and varies a few basic principles to generate a sheer endless number of sophisticated and highly effective recognition/regulation events.
PI3K: from the bench to the clinic and back.
- BiologyCurrent topics in microbiology and immunology
PI3K has become a very intense area of research, with over 2,000 publications on PI3K in PubMed for 2009 alone and progress in the clinical arena is being monitored by many.
Regulation of plant defense responses in Arabidopsis by EDR2, a PH and START domain-containing protein.
- BiologyThe Plant journal : for cell and molecular biology
EDR2 appears to be constitutively transcribed in all tissues and organs and encodes a novel protein, consisting of a putative pleckstrin homology (PH) domain and a steroidogenic acute regulatory protein-related lipid-transfer (START) domain, and contains an N-terminal mitochondrial targeting sequence.
DOS, a Novel Pleckstrin Homology Domain–Containing Protein Required for Signal Transduction between Sevenless and Ras1 in Drosophila
The role of PI3'‐lipid signalling in melanoma initiation, progression and maintenance
- BiologyExperimental dermatology
The different classes of PI3K‐lipid effectors, and how they may promote melanomagenesis, influence the tumour microenvironment, melanoma maintenance and progression to metastatic disease are described.
SHOWING 1-10 OF 19 REFERENCES
Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.
- BiologyProceedings of the National Academy of Sciences of the United States of America
The recently isolated Drosophila gene Son of sevenless (Sos) is postulated to act as a positive regulatory link between tyrosine kinase and ras proteins by catalyzing exchange of GDP for GTP on ras protein.
Molecular cloning of two types of GAP complementary DNA from human placenta.
The ras p21 GTPase-activating protein (GAP) was purified from human placental tissue and internal amino acid sequence was obtained and, by means of this sequence, two types of complementary DNA clones were isolated and characterized.
High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains.
- Biology, Computer ScienceProceedings of the National Academy of Sciences of the United States of America
This technique is modified by using T7 polymerase-based expression libraries, which significantly improves sensitivity of the method and should increase the ability to identify downstream modulators of growth factor action.
Molecular cloning of a second form of rac protein kinase.
- Biology, Computer ScienceCell regulation
The catalytic domain of rac protein kinases shows a high degree of homology to both the protein kinase C and cyclic AMP-dependentprotein kinase families, and hence racprotein kinases appear to represent a new subfamily of the second messenger serine/threonine protein kin enzymes.
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region.
- Biology, Computer ScienceScience
Sequence analysis of v-akt and biochemical characterization of its product revealed that it codes for a protein kinase C-related serine-threonine kinase whose cellular homolog is expressed in most tissues, with the highest amount found in thymus, suggesting that Akt may form a functional link between tyrosine and serinesine phosphorylation pathways.
Beta spectrin in human skeletal muscle. Tissue-specific differential processing of 3' beta spectrin pre-mRNA generates a beta spectrin isoform with a unique carboxyl terminus.
- BiologyThe Journal of biological chemistry
It is predicted that replacement, in nonerythroid cells, of the beta spectrin carboxyl terminus, known to participate in spectrin self-association and phosphorylation, has significant functional consequences, and this data may explain previously reported nonERYthroid beta spectrins isoforms that resemble red cell Beta spectrin by immunochemical analysis.
SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins.
- Biology, ChemistryScience
Observations suggest that SH2 and SH3 domains participate in the control of intracellular responses to growth factor stimulation.
cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19.
Cloning and sequencing of a human cDNA from cytolytic NK/T cells with homology to yeast SEC7.
- BiologyBiochimica et biophysica acta
Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase
- Biology, ChemistryMolecular and cellular biology
HBGF-1 joins epidermal growth factor and platelet-derived growth factor, whose receptor activation leads to tyrosine phosphorylation and probable activation of phospholipase C-gamma.