Pleckstrin domain homology

@article{Haslam1993PleckstrinDH,
  title={Pleckstrin domain homology},
  author={Richard J. Haslam and Hiroshi Koide and Brian A. Hemmings},
  journal={Nature},
  year={1993},
  volume={363},
  pages={309-310}
}
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References

SHOWING 1-10 OF 19 REFERENCES
Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides
Three-dimensional structures of complexes of the SH2 domain of the v-src oncogene product with two phosphotyrosyl peptides have been determined by X-ray crystallography at resolutions of 1.5 and 2.0
High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains.
TLDR
This technique is modified by using T7 polymerase-based expression libraries, which significantly improves sensitivity of the method and should increase the ability to identify downstream modulators of growth factor action.
Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.
TLDR
The recently isolated Drosophila gene Son of sevenless (Sos) is postulated to act as a positive regulatory link between tyrosine kinase and ras proteins by catalyzing exchange of GDP for GTP on ras protein.
Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21
TLDR
The cloning of complementary DNAs from a rat brain library that encode a ∼140 GRF for Ras p21 (p140Ras-GRF) is reported, which accelerated the release of GDP from RasH and RasN p21 in vitro, but not from the related RalA, or CDC42Hs GTP-binding proteins.
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region.
TLDR
Sequence analysis of v-akt and biochemical characterization of its product revealed that it codes for a protein kinase C-related serine-threonine kinase whose cellular homolog is expressed in most tissues, with the highest amount found in thymus, suggesting that Akt may form a functional link between tyrosine and serinesine phosphorylation pathways.
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.
TLDR
DNA sequence analysis identified an open reading frame of 1440 base pairs encoding a protein of 480 amino acids that was supported by the synthesis of a Mr 58,000 protein in an in vitro translation system that used RNA transcribed from cloned cDNAs with SP6 RNA polymerase.
Molecular cloning of a second form of rac protein kinase.
TLDR
The catalytic domain of rac protein kinases shows a high degree of homology to both the protein kinase C and cyclic AMP-dependentprotein kinase families, and hence racprotein kinases appear to represent a new subfamily of the second messenger serine/threonine protein kin enzymes.
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