# Playing the Devil's advocate: is the Hodgkin–Huxley model useful?

@article{Meunier2002PlayingTD, title={Playing the Devil's advocate: is the Hodgkin–Huxley model useful?}, author={Claude Meunier and Idan Segev}, journal={Trends in Neurosciences}, year={2002}, volume={25}, pages={558-563} }

Hodgkin and Huxley (H-H) model for action potential generation has held firm for half a century because this relatively simple and experimentally testable model embodies the major features of membrane nonlinearity: namely, voltage-dependent ionic currents that activate and inactivate in time. However, experimental and theoretical developments of the past 20 years force one to re-evaluate its usefulness. First, the H-H model is, in its original form, limited to the two voltage-dependent currents… Expand

#### 79 Citations

Improved Hodgkin-Huxley type model for neural action potentials.

- Medicine
- European biophysics journal : EBJ
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The simple Goldman-Hodgkin-Katz model for resting-state membrane potentials has been generalized to provide a new nonlinear theoretical model for action potentials in perfused axons that is in excellent agreement with the Hodgkin-Huxley experimental value. Expand

Phenomenological models of NaV1.5. A side by side, procedural, hands-on comparison between Hodgkin-Huxley and kinetic formalisms

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This study shows why simplified Markov-type kinetic models are more suitable for ion channels modelling as compared to HH ones, and how a manual optimization process can be rationally carried out for both. Expand

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A recent competition encouraged modelers to predict neuronal activity and launched an international competition that allowed a quantitative comparison of neuron models, resulting in a comparison of simple “integrate-and-fire” models. Expand

Phenomenological models of NaV1.5. A side by side, procedural, hands-on comparison between Hodgkin-Huxley and kinetic formalisms

- Biology, Computer Science
- 2019

Why kinetic, simplified models are better suited to model ionic channels compared to Hodgkin and Huxley models, and how the manual optimization process is rationally carried out in practice for these two kinds of models are shown. Expand

Dynamical response of the Hodgkin-Huxley model in the high-input regime.

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- Physical review. E, Statistical, nonlinear, and soft matter physics
- 2006

The response of the Hodgkin-Huxley neuronal model subjected to stochastic uncorrelated spike trains originating from a large number of inhibitory and excitatory post-synaptic potentials is analyzed… Expand

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The kinetic model, developed in the NEURON simulation environment, appears to be the simplest and most parsimonious way for a detailed phenomenological description of the human VGSCs electrophysiological behaviour. Expand

The response of cortical neurons to in vivo-like input current: theory and experiment: II. Time-varying and spatially distributed inputs

- Computer Science, Medicine
- Biological Cybernetics
- 2008

This article focuses on the response of integrate-and-fire neurons and real cortical neurons to long-lasting, noisy, in vivo-like stationary inputs and shows how the theory can predict the observed rhythmic activity of cultures of neurons. Expand

Interspike Interval Statistics in the Stochastic Hodgkin-Huxley Model: Coexistence of Gamma Frequency Bursts and Highly Irregular Firing

- Medicine, Computer Science
- Neural Computation
- 2007

The underlying mechanism is due to a subcritical Hopf bifurcation, together with a switching region in phase-space where a fixed point is very close to a system limit cycle and may contribute to widely observed highly irregular neural spiking. Expand

Validating Stochastic Models: Invariance Criteria for Systems of Stochastic Differential Equations and the Selection of a Stochastic Hodgkin-Huxley Type Model

- Mathematics
- 2012

In recent years, many difficulties appeared when taking into account the inherent stochastic behavior of neurons and voltage-dependent ion channels in Hodgking-Huxley type models. In particular, an… Expand

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- Medicine, Psychology
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A historico-scientific overview of the developments that have led to the current conception of the action potential as an electrical phenomenon is provided, some major objections against this conception are discussed, and a number of scientific factors are suggested which have likely contributed to the enduring success of the Hodgkin-Huxley model. Expand

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