Playing the Devil's advocate: is the Hodgkin–Huxley model useful?

@article{Meunier2002PlayingTD,
  title={Playing the Devil's advocate: is the Hodgkin–Huxley model useful?},
  author={Claude Meunier and Idan Segev},
  journal={Trends in Neurosciences},
  year={2002},
  volume={25},
  pages={558-563}
}
Hodgkin and Huxley (H-H) model for action potential generation has held firm for half a century because this relatively simple and experimentally testable model embodies the major features of membrane nonlinearity: namely, voltage-dependent ionic currents that activate and inactivate in time. However, experimental and theoretical developments of the past 20 years force one to re-evaluate its usefulness. First, the H-H model is, in its original form, limited to the two voltage-dependent currents… Expand
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