Playing Russian roulette with tyrosine kinase inhibitors.

@article{Szmulewitz2013PlayingRR,
  title={Playing Russian roulette with tyrosine kinase inhibitors.},
  author={Russell Z. Szmulewitz and Mark J. Ratain},
  journal={Clinical pharmacology and therapeutics},
  year={2013},
  volume={93 3},
  pages={
          242-4
        }
}
With the advent of molecularly “targeted therapies,” most notably the tyrosine kinase inhibitors (TKIs), there has been a significant shift in our formulary from intravenous to orally administered medications. The effect of food on bioavailability is a significant consideration for many drugs, especially those with a narrow therapeutic window. This article focuses on the complicated issue of oncology drug dosing with respect to food, highlighting the impact of food labeling on patient safety… CONTINUE READING
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