Players in the silencing of retroviral DNAs in embryonic stem cells

Abstract

Embryonic stem (ES) cells potently repress retroviral infection through transcriptional silencing of the newly established proviral DNAs. We have characterized two distinct types of silencing in embryonic mouse cells infected by the Moloney murine leukemia virus (MLV): a highly efficient one targeted to the proline tRNA primer binding site (PBSpro) on the… (More)
DOI: 10.1186/1742-4690-10-S1-O13

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