Platinum distribution in malignant glioma following intraoperative intravenous infusion of carboplatin.

@article{Whittle1999PlatinumDI,
  title={Platinum distribution in malignant glioma following intraoperative intravenous infusion of carboplatin.},
  author={Ian Whittle and Girvan Malcolm and Duncan I. Jodrell and M. McC. Reid},
  journal={British journal of neurosurgery},
  year={1999},
  volume={13 2},
  pages={132-7}
}
The objective of this paper was to determine the time course and extent of platinum uptake into human malignant glioma tissue. An intraoperative, intravenous infusion of carboplatin was given to nine patients (seven glioblastoma and two anaplastic glioma) undergoing tumour excision. Carboplatin dosage was calculated individually to achieve a target systemic free carboplatin exposure. Tumour and peritumoural tissue was harvested at timed intervals following carboplatin administration. Plasma and… CONTINUE READING

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