Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer.

@article{Choi2016PlatinumAP,
  title={Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer.},
  author={Young Eun Choi and Khyati Meghani and Marie-Eve Brault and Lucas Leclerc and Yizhou Joseph He and Tovah A. Day and Kevin M Elias and Ronny Drapkin and David M. Weinstock and Fanny Dao and Karin K. Shih and Ursula A. Matulonis and Douglas A. Levine and Panagiotis Konstantinopoulos and Dipanjan Chowdhury},
  journal={Cell reports},
  year={2016},
  volume={14 3},
  pages={429-439}
}
High-grade serous ovarian carcinomas (HGSOCs) with BRCA1/2 mutations exhibit improved outcome and sensitivity to double-strand DNA break (DSB)-inducing agents (i.e., platinum and poly(ADP-ribose) polymerase inhibitors [PARPis]) due to an underlying defect in homologous recombination (HR). However, resistance to platinum and PARPis represents a significant barrier to the long-term survival of these patients. Although BRCA1/2-reversion mutations are a clinically validated resistance mechanism… CONTINUE READING

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