Platforms for enrichment of phosphorylated proteins and peptides in proteomics.

  title={Platforms for enrichment of phosphorylated proteins and peptides in proteomics.},
  author={Iris Luz Batalha and Christopher Robin Lowe and Ana C. A. Roque},
  journal={Trends in biotechnology},
  volume={30 2},
Protein phosphorylation is a complex and highly dynamic process involved in numerous biological events. Abnormal phosphorylation is one of the underlying mechanisms for the development of cancer and metabolic disorders. The identification and absolute quantification of specific phospho-signatures can help elucidate protein functions in signaling pathways and facilitate the development of new and personalized diagnostic and therapeutic tools. This review presents a variety of strategies… CONTINUE READING
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