Platforms for antibiotic discovery

@article{Lewis2013PlatformsFA,
  title={Platforms for antibiotic discovery},
  author={Kim Swon Lewis},
  journal={Nature Reviews Drug Discovery},
  year={2013},
  volume={12},
  pages={371-387}
}
The spread of resistant bacteria, leading to untreatable infections, is a major public health threat but the pace of antibiotic discovery to combat these pathogens has slowed down. Most antibiotics were originally isolated by screening soil-derived actinomycetes during the golden era of antibiotic discovery in the 1940s to 1960s. However, diminishing returns from this discovery platform led to its collapse, and efforts to create a new platform based on target-focused screening of large… CONTINUE READING
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