Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients.

@article{Danese2003PlateletsTA,
  title={Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients.},
  author={Silvio Danese and Carol A. de la Motte and Andreas Sturm and Jon D. Vogel and G Alexander West and Scott A. Strong and Jeffry A. Katz and Claudio Fiocchi},
  journal={Gastroenterology},
  year={2003},
  volume={124 5},
  pages={1249-64}
}
BACKGROUND & AIMS Platelets circulate in an activated state in patients with inflammatory bowel disease (IBD), but their role in the pathogenesis of IBD is unclear. The recent demonstration that activated platelets express CD40 ligand (L) provides a mechanism of interaction with CD40-positive endothelial cells, inducing them to produce proinflammatory mediators. We investigated whether platelets from patients with IBD express enhanced levels of CD40L and induce human intestinal microvascular… CONTINUE READING

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