Platelets take up the monoclonal antibody bevacizumab.

  title={Platelets take up the monoclonal antibody bevacizumab.},
  author={Henk M. W. Verheul and Martijn P. J. K. Lolkema and David Qian and Yvonne H A Hilkes and Eleni Liapi and J W N Akkerman and Roberto Pili and Emile E Voest},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={13 18 Pt 1},
PURPOSE One of the key factors that promotes angiogenesis is vascular endothelial growth factor (VEGF). Platelets are the main source of VEGF in blood and contribute to angiogenesis by release of growth factors, including VEGF, from their alpha-granules on activation. The monoclonal antibody bevacizumab blocks VEGF in the blood of patients within hours after administration. Platelets are known to endocytose plasma proteins including immunoglobulins. We tested the hypothesis that platelets take… CONTINUE READING
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