Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling.

  title={Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling.},
  author={Cara C. Bertozzi and Alec A. Schmaier and Patricia Mericko and Paul R Hess and Zhiying Zou and Mei Chen and Chiu-Yu Chen and Bin Xu and Min-min Lu and Diane D Zhou and Eric Sebzda and Matthew T Santore and Demetri J Merianos and Matthias Stadtfeld and Alan W. Flake and Thomas Graf and Radek {\vS}koda and Jonathan Scott Maltzman and Gary A Koretzky and Mark L. Kahn},
  volume={116 4},
Although platelets appear by embryonic day 10.5 in the developing mouse, an embryonic role for these cells has not been identified. The SYK-SLP-76 signaling pathway is required in blood cells to regulate embryonic blood-lymphatic vascular separation, but the cell type and molecular mechanism underlying this regulatory pathway are not known. In the present study we demonstrate that platelets regulate lymphatic vascular development by directly interacting with lymphatic endothelial cells through… CONTINUE READING
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