Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus.

@article{Iannacone2008PlateletsPI,
  title={Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus.},
  author={Matteo Iannacone and Giovanni Sitia and Masanori Isogawa and Jason K Whitmire and Patrizia Marchese and Francis V. Chisari and Zaverio M. Ruggeri and Luca G. Guidotti},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 2},
  pages={629-34}
}
We found that mice infected with different isolates of lymphocytic choriomeningitis virus (LCMV) develop a mild hemorrhagic anemia, which becomes severe and eventually lethal in animals depleted of platelets or lacking integrin beta3. Lethal hemorrhagic anemia is mediated by virus-induced IFN-alpha/beta that causes platelet dysfunction, mucocutaneous blood loss and suppression of erythropoiesis. In addition to the life-threatening hemorrhagic anemia, platelet-depleted mice fail to mount an… CONTINUE READING
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