Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.

@article{Ma2001PlateletsMG,
  title={Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.},
  author={Li Ma and Susan N. Elliott and Giuseppe Antonio Cirino and Alain Buret and Louis Joseph Ignarro and John L Wallace},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 11},
  pages={6470-5}
}
Bleeding and delayed healing of ulcers are well recognized clinical problems associated with the use of aspirin and other nonsteroidal antiinflammatory drugs, which have been attributed to their antiaggregatory effects on platelets. We hypothesized that antiplatelet drugs might interfere with gastric ulcer healing by suppressing the release of growth factors, such as vascular endothelial growth factor (VEGF), from platelets. Gastric ulcers were induced in rats by serosal application of acetic… CONTINUE READING

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