Platelets interact with Coxsackieviruses B and have a critical role in the pathogenesis of virus-induced myocarditis.

@article{Negrotto2015PlateletsIW,
  title={Platelets interact with Coxsackieviruses B and have a critical role in the pathogenesis of virus-induced myocarditis.},
  author={Soledad Negrotto and Carolina Jaquenod de Giusti and Leonardo Rivadeneyra and Agust{\'i}n Enrique Ure and Hebe Agustina Mena and Mirta Schattner and Ricardo Mart{\'i}n G{\'o}mez},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2015},
  volume={13 2},
  pages={271-82}
}
BACKGROUND To further understand the role of platelets in the pathogenesis of viral infections we explored platelet interaction with Coxsackieviruses B (CVB) 1 and 3. CVB is a group of viruses that cause the majority of human enterovirus-related viral myocarditis; their receptor (CAR) is expressed on the platelet surface and there is a well-characterized CVB3-induced myocarditis murine model. METHODS Human platelets were infected with CVB1 and 3 and viruses were detected in pellets and in… CONTINUE READING