Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury.

@article{Caudrillier2012PlateletsIN,
  title={Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury.},
  author={Axelle Caudrillier and Kai Kessenbrock and Brian M Gilliss and John X Nguyen and Marisa B. Marques and Marc Monestier and Pearl Toy and Zena Werb and Mark R Looney},
  journal={The Journal of clinical investigation},
  year={2012},
  volume={122 7},
  pages={2661-71}
}
There is emerging evidence that platelets are major contributors to inflammatory processes through intimate associations with innate immune cells. Here, we report that activated platelets induce the formation of neutrophil extracellular traps (NETs) in transfusion-related acute lung injury (TRALI), which is the leading cause of death after transfusion therapy. NETs are composed of decondensed chromatin decorated with granular proteins that function to trap extracellular pathogens; their… CONTINUE READING
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Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

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