Platelets induce apoptosis via membrane-bound FasL.

@article{Schleicher2015PlateletsIA,
  title={Platelets induce apoptosis via membrane-bound FasL.},
  author={Rebecca Schleicher and Frank Reichenbach and Peter Kraft and Amit Kumar and Mario Lescan and Franziska Todt and Kerstin G{\"o}bel and Ingo Hilgendorf and Tobias Geisler and Axel Bauer and Marcus Olbrich and Martin Schaller and Sebastian Wesselborg and Lorraine A O'reilly and Sven G. Meuth and Klaus Schulze-Osthoff and Meinrad Gawaz and Xuri Li and C. Kleinschnitz and Frank Edlich and Harald F Langer},
  journal={Blood},
  year={2015},
  volume={126 12},
  pages={
          1483-93
        }
}
After tissue injury, both wound sealing and apoptosis contribute to restoration of tissue integrity and functionality. Although the role of platelets (PLTs) for wound closure and induction of regenerative processes is well established, the knowledge about their contribution to apoptosis is incomplete. Here, we show that PLTs present the death receptor Fas ligand (FasL) on their surface after activation. Activated PLTs as well as the isolated membrane fraction of activated PLTs but not of… CONTINUE READING

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