Platelets induce a proinflammatory phenotype in monocytes via the CD147 pathway in rheumatoid arthritis

@inproceedings{Rong2014PlateletsIA,
  title={Platelets induce a proinflammatory phenotype in monocytes via the CD147 pathway in rheumatoid arthritis},
  author={Meng-yao Rong and Cong-hua Wang and Zhen-biao Wu and Wen Zeng and Zhao-hui Zheng and Qing Han and Jun-feng Jia and Xue-yi Li and Ping Zhu},
  booktitle={Arthritis research & therapy},
  year={2014}
}
INTRODUCTION Activated platelets exert a proinflammatory action that can be largely ascribed to their ability to interact with monocytes. However, the mechanisms that promote dynamic changes in monocyte subsets in rheumatoid arthritis (RA) have not been clearly identified. The aim of this study was to determine whether platelet activation and the consequent formation of monocyte-platelet aggregates (MPA) might induce a proinflammatory phenotype in circulating monocytes in RA. METHODS The… CONTINUE READING
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Platelet Interaction with Innate Immune Cells.

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