Platelets are relevant mediators of renal injury induced by primary endothelial lesions.

@article{Schwarzenberger2015PlateletsAR,
  title={Platelets are relevant mediators of renal injury induced by primary endothelial lesions.},
  author={Claudia Schwarzenberger and Jan Sradnick and Kenneth M Lerea and Michael S. Goligorsky and Bernhard Nieswandt and Christian P. M. Hugo and Bernd Hohenstein},
  journal={American journal of physiology. Renal physiology},
  year={2015},
  volume={308 11},
  pages={F1238-46}
}
Several studies have suggested a prominent (pro)inflammatory and harmful role of platelets in renal disease, and newer work has also demonstrated platelet release of proangiogenic factors. In the present study, we investigated the role of platelets in a mouse model of selective endothelial cell injury using either platelet depletion or the pharmacological P2Y12 receptor blocker clopidogrel as an interventional strategy. The concanavalin A/anti-concanavalin A model was induced in left kidneys of… CONTINUE READING
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