Platelets and thrombin generation.

  title={Platelets and thrombin generation.},
  author={Dougald M Monroe and M. Hoffman and Harold R. Roberts},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={22 9},
This review examines the evidence that platelets play a major role in localizing and controlling the burst of thrombin generation leading to fibrin clot formation. From the first functional description of platelets, it has been recognized that platelets supply factors that support the activation of prothrombin. Studies have demonstrated that on activation, the amount of one specific lipid, phosphatidylserine, is significantly increased on the outer leaflet of platelet membranes. When it was… CONTINUE READING
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