Platelets actively sequester angiogenesis regulators.

  title={Platelets actively sequester angiogenesis regulators.},
  author={Giannoula Lakka Klement and Tai-tung Yip and Flavia Cassiola and Lena Kikuchi and David Cervi and Vladimir Podust and Joseph E. Italiano and Erin Wheatley and Abdo Abou-Slaybi and Elise R Bender and Nava Almog and Mark W Kieran and Judah M Folkman},
  volume={113 12},
Clinical trials with antiangiogenic agents have not been able to validate plasma or serum levels of angiogenesis regulators as reliable markers of cancer presence or therapeutic response. We recently reported that platelets contain numerous proteins that regulate angiogenesis. We now show that accumulation of angiogenesis regulators in platelets of animals bearing malignant tumors exceeds significantly their concentration in plasma or serum, as well as their levels in platelets from non-tumor… CONTINUE READING
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