Platelets Promote Liver Regeneration under Conditions of Kupffer Cell Depletion after Hepatectomy in Mice

@article{Murata2008PlateletsPL,
  title={Platelets Promote Liver Regeneration under Conditions of Kupffer Cell Depletion after Hepatectomy in Mice},
  author={Soichiro Murata and Ryota Matsuo and O Fujitsu Limited Ikeda and Andriy Myronovych and Motonobu Watanabe and Katsuji Hisakura and Yoritaka Nakano and Ikuka Hashimoto and Nobuhiro Ohkohchi},
  journal={World Journal of Surgery},
  year={2008},
  volume={32},
  pages={1088-1096}
}
Platelets have been proven to promote liver regeneration after hepatectomy. Kupffer cells produce inflammatory cytokines and also promote liver regeneration. In the present study, we examined whether platelets promote liver regeneration after hepatectomy under conditions of Kupffer cell depletion. Seventy percent hepatectomy was carried out in mice, which were subsequently divided into four groups: (1) a normal group without any treatment, (2) a Kupffer cell depleted (KD) group, (3) a… CONTINUE READING
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