Platelets Alter Gene Expression Profile in Human Brain Endothelial Cells in an In Vitro Model of Cerebral Malaria

@inproceedings{Barbier2011PlateletsAG,
  title={Platelets Alter Gene Expression Profile in Human Brain Endothelial Cells in an In Vitro Model of Cerebral Malaria},
  author={Mathieu Barbier and Doroth{\'e}e Faille and B{\'e}atrice Loriod and Julien Textoris and Claire Camus and Denis Puthier and Laurence Flori and Samuel C Wassmer and Genevi{\`e}ve Victorero and M K Alessi and Thierry Fusa{\"i} and Catherine Nguyen and Georges Emile Raymond Grau and Pascal Rihet},
  booktitle={PloS one},
  year={2011}
}
Platelet adhesion to the brain microvasculature has been associated with cerebral malaria (CM) in humans, suggesting that platelets play a role in the pathogenesis of this syndrome. In vitro co-cultures have shown that platelets can act as a bridge between Plasmodium falciparum-infected red blood cells (pRBC) and human brain microvascular endothelial cells (HBEC) and potentiate HBEC apoptosis. Using cDNA microarray technology, we analyzed transcriptional changes of HBEC in response to platelets… CONTINUE READING

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