Platelets: production, morphology and ultrastructure.

  title={Platelets: production, morphology and ultrastructure.},
  author={Jonathan N Thon and Joseph E. Italiano},
  journal={Handbook of experimental pharmacology},
Platelets are anucleate, discoid cells, roughly 2-3 μm in diameter that function primarily as regulators of hemostasis, but also play secondary roles in angiogensis and innate immunity. Although human adults contain nearly one trillion platelets in circulation that are turned over every 8-10 days, our understanding of the mechanisms involved in platelet production is still incomplete. Platelets stem from large (30-100 μm) nucleated cells called megakaryocytes that reside primarily in the bone… CONTINUE READING

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