Platelet ultrastructural abnormalities in three patients with type 2B von Willebrand disease.

@article{Nurden2000PlateletUA,
  title={Platelet ultrastructural abnormalities in three patients with type 2B von Willebrand disease.},
  author={Paquita Nurden and Fabrice C Chr{\'e}tien and Christel Poujol and Joelle Winckler and Annie Borel-Derlon and A. Van Nurden},
  journal={British journal of haematology},
  year={2000},
  volume={110 3},
  pages={704-14}
}
Several reports have described the presence of giant platelets in patients with type 2B von Willebrand disease (VWD). We have now characterized the ultrastructural changes in platelets from three unrelated patients with type 2B VWD and different mutations within exon 28 of the von Willebrand factor (VWF) gene. Electron microscopy showed that each of these subjects had an increased proportion of large platelets when compared with those of a patient with type 2A VWD or control subjects… CONTINUE READING

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