Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice.

@article{Drschmied2013PlateletSP,
  title={Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice.},
  author={Daniel D{\"u}rschmied and Georgette L. Suidan and M{\'e}lanie Demers and Nadine Herr and Carla Carbo and Alexander Brill and Stephen M. Cifuni and Maximilian Mauler and Sanja Cicko and Michael Bader and Marco Idzko and Christoph Bode and Denisa D Wagner},
  journal={Blood},
  year={2013},
  volume={121 6},
  pages={1008-15}
}
The majority of peripheral serotonin is stored in platelets, which secrete it on activation. Serotonin releases Weibel-Palade bodies (WPBs) and we asked whether absence of platelet serotonin affects neutrophil recruitment in inflammatory responses. Tryptophan hydroxylase (Tph)1–deficient mice, lacking non-neuronal serotonin, showed mild leukocytosis compared with wild-type (WT), primarily driven by an elevated neutrophil count. Despite this, 50% fewer leukocytes rolled on unstimulated… CONTINUE READING

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