Platelet-rich plasma increases matrix metalloproteinases in cultures of human synovial fibroblasts.

Abstract

BACKGROUND The effect of platelet-rich plasma on chondrocytes has been studied in cell and tissue culture. Less attention has been given to the effect of platelet-rich plasma on nonchondrocytic cell lineages within synovial joints, such as fibroblast-like synoviocytes, which produce cytokines and matrix metalloproteinases (MMPs) that mediate cartilage… (More)
DOI: 10.2106/JBJS.K.01501

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