Platelet response heterogeneity in thrombus formation.

@article{Munnix2009PlateletRH,
  title={Platelet response heterogeneity in thrombus formation.},
  author={Imke C. A. Munnix and Judith M.E.M. Cosemans and Jocelyn M. Auger and Johan W. M. Heemskerk},
  journal={Thrombosis and haemostasis},
  year={2009},
  volume={102 6},
  pages={
          1149-56
        }
}
Vascular injury leads to formation of a structured thrombus as a consequence of platelet activation and aggregation, thrombin and fibrin formation, and trapping of leukocytes and red cells. This review summarises current evidence for heterogeneity of platelet responses and functions in the thrombus-forming process. Environmental factors contribute to response heterogeneity, as the platelets in a thrombus adhere to different substrates, and sense specific (ant)agonists and rheological conditions… 

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