Platelet release of beta-thromboglobulin and platelet factor 4 and serotonin in plasma samples.

@article{Ohkawa2005PlateletRO,
  title={Platelet release of beta-thromboglobulin and platelet factor 4 and serotonin in plasma samples.},
  author={Ryunosuke Ohkawa and Yuji Hirowatari and Kazuhiro Nakamura and Shigeo Ohkubo and Hitoshi Ikeda and Mitsumasa Okada and Minoru Tozuka and Kazuhiko Nakahara and Yutaka Yatomi},
  journal={Clinical biochemistry},
  year={2005},
  volume={38 11},
  pages={1023-6}
}
OBJECTIVES Platelet release of alpha granule-derived CXC chemokines and dense granule-derived serotonin in plasma samples was evaluated. METHODS Concentrations of the CXC chemokines beta-TG and PF4 were assayed by an enzyme immunoassay; serotonin was measured by an HPLC method. RESULTS Beta-TG and PF4 were more easily released than serotonin by in vitro procedures. Use of the anti-platelet cocktail CTAD and preservation of the samples at 4 degrees C were necessary to accurately measure beta… CONTINUE READING
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