Platelet receptor recognition domain on the gamma chain of human fibrinogen and its synthetic peptide analogues.

@article{Kloczewiak1989PlateletRR,
  title={Platelet receptor recognition domain on the gamma chain of human fibrinogen and its synthetic peptide analogues.},
  author={M. Kloczewiak and Sheila Timmons and Maria A. Bednarek and Masato Sakon and Jack Hawiger},
  journal={Biochemistry},
  year={1989},
  volume={28 7},
  pages={
          2915-9
        }
}
We have shown previously that the domain recognizing receptors on activated human platelets is located on the human fibrinogen gamma chain between residues 400 and 411 [Kloczewiak, M., Timmons, S., Lukas, T. J., & Hawiger, J. (1984) Biochemistry 23, 1767]. To study the correlation between the structure of this segment of the gamma chain and its reactivity toward receptors on ADP-activated human platelets, we designed a series of analogues containing replacements at 9 out of 12 positions. A… CONTINUE READING
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