Platelet receptor polymorphisms and thrombotic risk.

  title={Platelet receptor polymorphisms and thrombotic risk.},
  author={S. H. Urip Santoso and Tom Kunicki},
  journal={Italian heart journal : official journal of the Italian Federation of Cardiology},
  volume={2 11},
Plaque rupture and/or endothelial damage lead to exposure of von Willebrand factor and collagen which facilitate the adhesion of circulating platelets via glycoprotein Ib-IX-V and the integrin alpha2 beta1, respectively, to the damaged vessel wall. This process activates the platelet and leads to a conformational change of a second integrin alphaIIb beta3 that facilitates fibrinogen binding and platelet aggregation. Thrombin generated at the blood-plaque interface converts fibrinogen to fibrin… CONTINUE READING